Gtf2h1 Gene Summary [Rat]
Enables chromatin binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human GTF2H1 (general transcription factor IIH subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtf2h1 |
| Official Name | general transcription factor IIH subunit 1 [Source:RGD Symbol;Acc:1308225] |
| Ensembl ID | ENSRNOG00000012360 |
| Bio databases IDs | |
| Aliases | general transcription factor IIH subunit 1 |
| Synonyms | BTF2, BTF2 p62, GENERAL TRANSCRIPTION FACTOR IIH 1, general transcription factor II H, polypeptide 1, general transcription factor IIH subunit 1, P62, p62 TFIIH, TFB1, TFIIH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gtf2h1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- domain in transcription factors and synapse-associated proteins
- transcription regulator
- BSD domain
- chromatin binding
- protein binding
- Pleckstrin homology-like domain
- thyroid hormone receptor binding
- TFIIH p62 subunit, N-terminal domain
Pathways
Biological processes and signaling networks where the Gtf2h1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- pancreatic carcinoma
- pancreatic epithelial cancer
- overall survival
- productive infection by HIV-1
regulates
- DNA promoter
- DNA endogenous promoter
- Ad2
- RNA polymerase II
role in cell
- cell cycle progression
- JQ1-sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gtf2h1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of transcription, DNA-dependent
- transcription from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
- nucleotide-excision repair
- transcription initiation from RNA polymerase II promoter
- hormone-mediated signaling pathway
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- core TFIIH complex
- holo TFIIH complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding
- thyroid hormone receptor binding