ELOA Gene Summary [Human]
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ELOA |
| Official Name | elongin A [Source:HGNC Symbol;Acc:HGNC:11620] |
| Ensembl ID | ENSG00000011007 |
| Bio databases IDs | |
| Aliases | elongin A |
| Synonyms | El, ELOA1, Elongin A, SIII, SIII p110, TCEB3, TCEB3A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELOA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- transcription regulator
- TFIIS helical bundle-like domain
- double-stranded DNA binding
- RNA polymerase II transcription factor SIII (Elongin) subunit A
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- developmental delay
- hypoplasia
- psoriasis
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- organismal death
- growth failure
- gastric cancer
- infection by HIV-1
regulated by
- dexamethasone
- thapsigargin
- triptolide
- alpha-amanitin
- histidinol
- methyl methanesulfonate
- olaparib
- dichlororibofuranosylbenzimidazole
- tretinoin
- ELOC
role in cell
- binding in
- migration
- expression in
- cell death
- apoptosis
- growth
- proliferation
- dissociation in
- degradation in
- JQ1 resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELOA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- extracellular space
- elongin complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding