Mme

Enables oligopeptidase activity and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; placenta development; and response to estrogen. Predicted to be located in several cellular components, including cytoplasmic vesicle; microtubule organizing center; and trans-Golgi network. Predicted to be active in extracellular region and plasma membrane. Used to study diarrhea and hypertension. Biomarker of Alzheimer's disease; congestive heart failure; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mme often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Mme gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Mme gene, providing context for its role in the cell.