Rapsn Gene Summary [Rat]
Enables ionotropic glutamate receptor binding activity. Involved in establishment of protein localization to postsynaptic membrane; positive regulation of neuromuscular synaptic transmission; and regulation of postsynaptic membrane organization. Located in neuromuscular junction. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 11 and fetal akinesia deformation sequence syndrome 2. Orthologous to human RAPSN (receptor associated protein of the synapse). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rapsn |
| Official Name | receptor-associated protein of the synapse [Source:RGD Symbol;Acc:1311592] |
| Ensembl ID | ENSRNOG00000011208 |
| Bio databases IDs | |
| Aliases | receptor-associated protein of the synapse |
| Synonyms | CMS11, CMS4C, FADS, FADS2, Nraps, Postsynaptic 43 kDa, Raps, RAPSYN, receptor-associated protein of the synapse, RNF205 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rapsn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
- protein binding activity, bridging
- coiled-coil domain
- Ring finger domain
- protein binding
- receptor binding
- ionotropic glutamate receptor binding
- myristoylation sequence
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Rapsyn N-terminal myristoylation and linker region
- zinc finger domain
- structural molecule
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Rapsn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- open-angle glaucoma
- congenital myasthenic syndrome associated with acetylcholine receptor deficiency type 11
- major depression
- prostatic carcinoma
- prostate cancer
- fetal akinesia deformation sequence 2
- hereditary disorder
- muscle weakness
- congenital myasthenic syndrome
role in cell
- activation in
- synaptic transmission
- morphology
- apoptosis
- quantity
- survival
- formation
- development
- fragmentation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- focal adhesions
- vesicles
- centrosome
- Golgi Apparatus
- cytosol
- postsynaptic membrane
- synaptic membrane
- neuromuscular junctions
- synapse
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rapsn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- skeletal muscle acetylcholine-gated channel clustering
- motor neuron apoptotic process
- positive regulation of neuromuscular synaptic transmission
- synaptic transmission
- positive regulation of motor neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytosol
- neuromuscular junction
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding
- metal ion binding
- protein anchor
- acetylcholine receptor binding