Chrnd Gene Summary [Rat]
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 3A; congenital myasthenic syndrome 3B; and congenital myasthenic syndrome 3C. Orthologous to human CHRND (cholinergic receptor nicotinic delta subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrnd |
| Official Name | cholinergic receptor nicotinic delta subunit [Source:RGD Symbol;Acc:2352] |
| Ensembl ID | ENSRNOG00000019527 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic delta subunit |
| Synonyms | Achr-4, ACHRD, AchR δ, Acrd, cholinergic receptor, nicotinic, delta polypeptide, cholinergic receptor nicotinic delta subunit, cholinergic receptor, nicotinic, δ polypeptide, cholinergic receptor nicotinic δ subunit, CMS2A, CMS3A, CMS3B, CMS3C, FCCMS, nAChR δ, SCCMS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrnd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- acetylcholine binding
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrnd gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- bladder cancer
- coronary disease
- chronic obstructive pulmonary disease
- renal failure
- stroke
- COVID-19
- acute respiratory distress syndrome
- psychological disorder
- depressive disorder
role in cell
- expression in
- transmembrane potential
- gating in
- autophagy in
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synaptic membrane
- neuromuscular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrnd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- ion transmembrane transport
- neuromuscular process
- synaptic transmission
- musculoskeletal movement
- cation transport
- skeletal muscle contraction
- skeletal muscle tissue growth
- muscle contraction
- membrane depolarization
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- neuromuscular junction
- acetylcholine-gated channel complex
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor activity
- acetylcholine-gated cation channel activity
- acetylcholine binding