Papss1 Gene Summary [Rat]
Predicted to enable adenylylsulfate kinase activity; protein homodimerization activity; and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Predicted to be active in cytosol and nucleus. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Papss1 |
| Official Name | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [Source:RGD Symbol;Acc:1308081] |
| Ensembl ID | ENSRNOG00000011311 |
| Bio databases IDs | |
| Aliases | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| Synonyms | 3'-phosphoadenosine 5'-phosphosulfate synthase 1, Asapk, ATPSK1, PAPSS, PAPS SYNTHETASE, SK1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Papss1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotidyltransferase
- adenylyl-sulfate kinase
- ATP sulphurylase
- enzyme
- protein binding
- AAA domain
- sulfate adenylyltransferase
- PUA-like domain
- NK
- ATP-sulfurylase
- protein homodimerization
- sulfate adenylyltransferase (ATP)
- P-loop containing Nucleoside Triphosphate Hydrolases
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Papss1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
- sulfate assimilation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- nucleotidyltransferase activity
- protein homodimerization activity
- adenylylsulfate kinase activity
- sulfate adenylyltransferase (ATP) activity