Papss1 Gene Summary [Mouse]
Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process. Predicted to be part of sulfate adenylyltransferase complex (ATP). Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Papss1 |
| Official Name | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [Source:MGI Symbol;Acc:MGI:1330587] |
| Ensembl ID | ENSMUSG00000028032 |
| Bio databases IDs | |
| Aliases | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| Synonyms | 3'-phosphoadenosine 5'-phosphosulfate synthase 1, Asapk, ATPSK1, PAPSS, PAPS SYNTHETASE, SK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Papss1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotidyltransferase
- adenylyl-sulfate kinase
- ATP sulphurylase
- enzyme
- protein binding
- AAA domain
- sulfate adenylyltransferase
- PUA-like domain
- NK
- ATP-sulfurylase
- protein homodimerization
- sulfate adenylyltransferase (ATP)
- P-loop containing Nucleoside Triphosphate Hydrolases
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Papss1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
- sulfate assimilation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- nucleotidyltransferase activity
- protein homodimerization activity
- adenylylsulfate kinase activity
- sulfate adenylyltransferase (ATP) activity