PAPSS1 Gene Summary [Human]
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PAPSS1 |
| Official Name | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [Source:HGNC Symbol;Acc:HGNC:8603] |
| Ensembl ID | ENSG00000138801 |
| Bio databases IDs | |
| Aliases | 3'-phosphoadenosine 5'-phosphosulfate synthase 1, sulfate adenylyltransferase, adenylyl-sulfate kinase |
| Synonyms | 3'-phosphoadenosine 5'-phosphosulfate synthase 1, Asapk, ATPSK1, PAPSS, PAPS SYNTHETASE, SK1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAPSS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotidyltransferase
- adenylyl-sulfate kinase
- ATP sulphurylase
- enzyme
- protein binding
- AAA domain
- sulfate adenylyltransferase
- PUA-like domain
- NK
- ATP-sulfurylase
- protein homodimerization
- sulfate adenylyltransferase (ATP)
- P-loop containing Nucleoside Triphosphate Hydrolases
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAPSS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
- sulfate assimilation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- nucleotidyltransferase activity
- protein homodimerization activity
- adenylylsulfate kinase activity
- sulfate adenylyltransferase (ATP) activity