Cnn3 Gene Summary [Rat]
Enables microtubule binding activity. Involved in negative regulation of ATP-dependent activity. Located in dendritic spine and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Orthologous to human CNN3 (calponin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnn3 |
| Official Name | calponin 3 [Source:RGD Symbol;Acc:71044] |
| Ensembl ID | ENSRNOG00000011559 |
| Bio databases IDs | |
| Aliases | calponin 3 |
| Synonyms | 1600014M03Rik, Acidic Calponin, Calpo3, calponin 3, calponin 3, acidic |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cnn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Calponin homology domain
- Calponin family repeat
- calponin homology (CH) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Duchenne muscular dystrophy
- atopic dermatitis
- autosomal dominant Emery-Dreifuss muscular dystrophy
- idiopathic pulmonary fibrosis
- juvenile dermatomyositis
- exencephaly
role in cell
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- somatodendritic region
- perinuclear region
- postsynaptic region
- actin cytoskeleton
- cell cortex
- Nucleus
- microtubules
- actin filaments
- cytosol
- plasma membrane projections
- dendritic spines
- growth cone
- neurites
- fibrils
- microfilaments
- cellular protrusions
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cnn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- actomyosin structure organization
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- adherens junction
- focal adhesion
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calmodulin binding