Map2 Gene Summary [Rat]
Enables SH2 domain binding activity; cytoskeletal protein binding activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of vesicle transport along microtubule; and response to progesterone. Located in several cellular components, including axon; cytoskeleton; and dendrite. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Used to study Alzheimer's disease and cerebral infarction. Biomarker of arteriovenous malformation; asphyxia neonatorum; brain ischemia; sciatic neuropathy; and temporal lobe epilepsy. Orthologous to human MAP2 (microtubule associated protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map2 |
| Official Name | microtubule-associated protein 2 [Source:RGD Symbol;Acc:3044] |
| Ensembl ID | ENSRNOG00000011841 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein 2 |
| Synonyms | Autoantigen M2, G1-397-34, M2, M2 mitochondrial autoantigen, MAP2R, microtubule-associated protein 2, MTAP2, repro4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Map2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PXXP Class I motif
- microtubule binding domain
- Tau and MAP protein, tubulin-binding repeat
- inter-repeat domain
- protein kinase binding
- MAP2/Tau projection domain
- SH2-domain binding
- R2 binding domain
- protein binding
- cytoskeletal regulatory protein binding
- proline rich domain
- projection domain
- microtubule binding
- actin binding
- tau-like microtubule binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- cervical cancer
- prostate cancer
- dementia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- prostatic neoplasm
- Huntington disease
- anxiety disorder
role in cell
- migration
- transformation
- development
- formation
- binding
- organization
- assembly
- attachment
- extension
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- membrane fraction
- dendrite tip
- basal dendrites
- glutaminergic synapse
- microtubule cytoskeleton
- axon component
- Cytoplasm
- cilia
- cell surface
- intracellular space
- somatodendritic region
- postsynaptic region
- cellular membrane
- actin cytoskeleton
- ribosome
- Nucleus
- Golgi Apparatus
- microtubules
- microtubule bundles
- cytosol
- membrane ruffles
- axon hillock
- growth cone
- neurites
- dendrite initial segments
- synapse
- neuritic shafts
- membrane processes
- filopodia
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- dendritic branches
- apical processes
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Map2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- negative regulation of axon extension
- regulation of protein localization
- regulation of microtubule polymerization
- central nervous system neuron development
- microtubule cytoskeleton organization
- dendrite development
- dendrite morphogenesis
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- dendritic branch
- neuronal cell body
- main axon
- axon hillock
- neuron projection
- microtubule associated complex
- microtubule
- dendrite
- dendritic growth cone
- initial segment
- cytoplasm
- dendritic shaft
- dendrite cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- tau protein binding
- structural molecule activity
- dystroglycan binding
- microtubule binding