Pmch Gene Summary [Rat]
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | Pmch |
| Official Name | pro-melanin-concentrating hormone [Source:RGD Symbol;Acc:3358] |
| Ensembl ID | ENSRNOG00000004632 |
| Bio databases IDs | |
| Aliases | pro-melanin-concentrating hormone |
| Synonyms | A230109K23RIK, ppMCH, pro-melanin-concentrating hormone |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pmch often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- Pro-melanin-concentrating hormone (Pro-MCH)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hyperphagia
- eosinophilic esophagitis
- colon adenocarcinoma
- colon epithelial cancer
- weight gain
- tumorigenesis
- weight loss
role in cell
- expression in
- migration
- signaling in
- size
- hyperpolarization
- elevation in
- plasticity
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Golgi Apparatus
- trans face of the Golgi apparatus
- dendritic spines
- rough endoplasmatic reticulum
- perikaryon
- axons
- dendrites
- axon terminals
- dendritic branches
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pmch gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- spermatogenesis
- cell differentiation
- synaptic transmission
- feeding behavior
- behavior
Cellular Component
Where in the cell the gene product is active
- nucleus
- synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- melanin-concentrating hormone activity
- type 1 melanin-concentrating hormone receptor binding