Pcsk6 Gene Summary [Rat]
Predicted to enable heparin binding activity; nerve growth factor binding activity; and serine-type endopeptidase activity. Involved in peptide hormone processing. Predicted to be active in several cellular components, including cell surface; collagen-containing extracellular matrix; and extracellular space. Orthologous to human PCSK6 (proprotein convertase subtilisin/kexin type 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcsk6 |
| Official Name | proprotein convertase subtilisin/kexin type 6 [Source:RGD Symbol;Acc:3246] |
| Ensembl ID | ENSRNOG00000011526 |
| Bio databases IDs | |
| Aliases | proprotein convertase subtilisin/kexin type 6 |
| Synonyms | b2b2830Clo, PACE4, PAIRED BASIC AMINO ACID CLEAVING ENZYME 4, proprotein convertase subtilisin/kexin type 6, SPC4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcsk6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase S8 pro-domain
- Giardia variant-specific surface protein
- Growth factor receptor domain IV
- Subtilase family
- peptidase
- PLAC (protease and lacunin) domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- Peptidase domain in the S8 and S53 families
- FU
- endopeptidase
- serine endopeptidase
- Proprotein convertase P-domain
- Furin-like repeat, cysteine-rich
- Furin-like repeats
- pro domain
- heparin binding
- growth factor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- major depression
- hypertension
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- COVID-19
- breast cancer
- glioblastoma
role in cell
- proliferation
- cell viability
- molecular cleavage in
- disruption
- invasiveness
- migratory capacity
- processing in
- activation in
- motility
- conversion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- cell surface
- Plasma Membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcsk6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nerve growth factor production
- glycoprotein metabolic process
- plasma lipoprotein particle remodeling
- protein processing
- peptide hormone processing
- zygotic determination of anterior/posterior axis, embryo
- regulation of BMP signaling pathway
- secretion by cell
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- endoplasmic reticulum
- Golgi lumen
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- serine-type endopeptidase activity
- heparin binding
- nerve growth factor binding