Fam111a Gene Summary [Rat]
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process; negative regulation of viral genome replication; and protein autoprocessing. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Kenny-Caffey syndrome type 2. Orthologous to human FAM111A (FAM111 trypsin like peptidase A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam111a |
| Official Name | family with sequence similarity 111, member A [Source:RGD Symbol;Acc:1560913] |
| Ensembl ID | ENSRNOG00000012067 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 111, member A |
| Synonyms | 4632417K18Rik, FAM111 trypsin like peptidase A, family with sequence similarity 111, member A, FLJ22794, GCLEB, KCS2, RGD1560913 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fam111a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tryp_SPc
- single-stranded DNA binding
- Trypsin-like peptidase domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- Kenny-Caffey syndrome type 2
- glioblastoma
- glioblastoma cancer
- gracile bone dysplasia
role in cell
- production in
- apoptosis
- cell viability
- replication in
- association
- association in
- transcription in
- DNA damage response
- processing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fam111a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- proteolysis
- replication fork processing
- protein autoprocessing
- response to DNA damage stimulus
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptidase activity
- single-stranded DNA binding