Rfc1 Gene Summary [Rat]
Enables DNA binding activity; DNA-binding transcription factor binding activity; and protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of DNA-templated transcription. Located in nucleus. Part of protein-containing complex. Human ortholog(s) of this gene implicated in West Nile fever and congenital heart disease. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rfc1 |
| Official Name | replication factor C subunit 1 [Source:RGD Symbol;Acc:620619] |
| Ensembl ID | ENSRNOG00000002855 |
| Bio databases IDs | |
| Aliases | replication factor C subunit 1 |
| Synonyms | A1, Alp145, CANVAS, Dseb, MHCBFB, Pcrhreb1, PO-GA, RECC1, Replication factor c, replication factor C (activator 1) 1, replication factor C subunit 1, RFC, RFC140, RF-C 140 kDa subunit, RFCp140, VIPR-RP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rfc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ligase-like domain
- PCNA binding domain
- BRCT
- magnesium binding domain
- transcription regulator
- DNA binding domain
- ATP-binding domain
- ATP binding
- transcription factor binding
- protein domain specific binding
- protein binding
- LXCXE binding site
- DNA dependent ATPase
- enzyme activator activity
- sequence-specific DNA binding
- Replication factor RFC1 C terminal domain
- ATPase family associated with various cellular activities (AAA)
- helical lid domain of clamp loader-like AAA+ proteins
- double-stranded DNA binding
- BRCA1 C Terminus (BRCT) domain
- breast cancer carboxy-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Rfc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- epithelial cancer
- cerebellar ataxia, neuropathy and vestibular areflexia syndrome
- high-grade serous carcinoma
role in cell
- cell death
- growth
- apoptosis
- survival
- frequency
- recruitment in
- telomere-length maintenance
- homologous recombination in
- synthesis in
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear foci
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rfc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- DNA repair
- positive regulation of transcription, DNA-dependent
- DNA-dependent DNA replication
- telomere maintenance via telomerase
Cellular Component
Where in the cell the gene product is active
- nucleus
- Elg1 RFC-like complex
- extracellular vesicular exosome
- DNA replication factor C complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- protein domain specific binding
- DNA clamp loader activity
- protein binding
- double-stranded DNA binding
- sequence-specific DNA binding
- enzyme activator activity