Chat Gene Summary [Rat]
Enables choline O-acetyltransferase activity and choline binding activity. Involved in several processes, including acetylcholine biosynthetic process; antral ovarian follicle growth; and response to ethanol. Predicted to be located in axon and neuronal cell body. Predicted to be active in cytoplasm and neuron projection. Used to study depressive disorder. Biomarker of Alzheimer's disease; asthma; and depressive disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chat |
| Official Name | choline O-acetyltransferase [Source:RGD Symbol;Acc:1304627] |
| Ensembl ID | ENSRNOG00000025012 |
| Bio databases IDs | |
| Aliases | choline O-acetyltransferase |
| Synonyms | B230380D24Rik, CHOACTASE, CHOLINE ACETYLTRANSFERASE, choline O-acetyltransferase, CMS1A, CMS1A2, CMS6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Choline/Carnitine o-acyltransferase
- choline O-acetyltransferase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Chat gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- congenital myasthenic syndrome associated with episodic type apnea
- Huntington disease
- Alzheimer disease
- pruritus
- late-onset Alzheimer disease
- congenital myasthenic syndrome
- small cell lung cancer
- cyanosis
- cataplexy
role in cell
- cell death
- proliferation
- formation
- differentiation
- quantity
- number
- abnormal morphology
- development
- size
- establishment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- somatodendritic region
- perinuclear region
- Plasma Membrane
- cytosol
- neurites
- membrane processes
- perikaryon
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter transport
- acetylcholine biosynthetic process
- neuromuscular synaptic transmission
- phosphatidylcholine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- synapse
- neuron projection
Molecular Function
What the gene product does at the molecular level
- choline O-acetyltransferase activity