Gas2l1 Gene Summary [Rat]
Predicted to enable actin filament binding activity; cytoskeletal anchor activity; and microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; negative regulation of microtubule depolymerization; and protein localization to microtubule plus-end. Predicted to be located in actin filament and microtubule. Predicted to be active in cytoplasm. Predicted to colocalize with microtubule plus-end and stress fiber. Orthologous to human GAS2L1 (growth arrest specific 2 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gas2l1 |
| Official Name | growth arrest-specific 2 like 1 [Source:RGD Symbol;Acc:1311206] |
| Ensembl ID | ENSRNOG00000009040 |
| Bio databases IDs | |
| Aliases | growth arrest-specific 2 like 1 |
| Synonyms | 4930500E24RIK, D0Jmb1, GAR22, growth arrest-specific 2 like 1, MGC17243, TU-71.1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gas2l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Calponin homology domain
- calponin homology (CH) domain superfamily
- protein binding
- glycine arginine rich domain
- Growth-Arrest-Specific Protein 2 Domain
- cytoskeletal adaptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
role in cell
- morphology
- binding in
- density
- quantity
- assembly
- assembly in
- formation
- length
- motility
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- actin filaments
- sperm head
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gas2l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin crosslink formation
- microtubule bundle formation
- regulation of microtubule polymerization or depolymerization
- cellular response to starvation
Cellular Component
Where in the cell the gene product is active
- microtubule plus end
- cytoplasm
- stress fiber
- actin filament
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- cytoskeletal adaptor activity
- protein binding
- microtubule binding