Dennd5a Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in negative regulation of neuron projection development. Predicted to be located in Golgi apparatus. Predicted to be part of retromer complex. Predicted to be active in trans-Golgi network. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 49. Orthologous to human DENND5A (DENN domain containing 5A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dennd5a |
| Official Name | DENN domain containing 5A [Source:RGD Symbol;Acc:1306759] |
| Ensembl ID | ENSRNOG00000012206 |
| Bio databases IDs | |
| Aliases | DENN domain containing 5A |
| Synonyms | 1500012B19Rik, DEE49, DENN domain containing 5A, EIEE49, mKIAA1091, ORF37, RAB6IP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dennd5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- domain involved in Ras-like GTPase signaling
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- dDENN domain
- PLAT
- enzyme binding
- protein binding
- uDENN domain
- RUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dennd5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron projection development
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- retromer complex
- cytosol
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding