Skap2 Gene Summary [Rat]
Predicted to be involved in B cell activation. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human SKAP2 (src kinase associated phosphoprotein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Skap2 |
| Official Name | src kinase associated phosphoprotein 2 [Source:RGD Symbol;Acc:620159] |
| Ensembl ID | ENSRNOG00000012228 |
| Bio databases IDs | |
| Aliases | src kinase associated phosphoprotein 2 |
| Synonyms | 2610021A10Rik, mSKAP55R, PRAP, RA70, SAPS, SCAP2, Scap55r, SKAP55R, SKAP-HOM, src family associated phosphoprotein 2, src kinase associated phosphoprotein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Skap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- neoplasia
- small cell lung cancer
- inflammatory bowel disease
- insulin-dependent diabetes mellitus
- dextran sodium sulfate-induced colitis
- multiple sclerosis
- systemic lupus erythematosus
- chronic venous insufficiency
- lung metastasis
role in cell
- migration
- expression in
- activation in
- formation
- formation in
- phosphorylation in
- invasion by
- binding in
- proliferation
- infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- podosomes
- Plasma Membrane
- cytosol
- nucleoplasm
- cell membrane leading edge
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Skap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
- B cell activation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding