Gchfr Gene Summary [Rat]
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Gchfr |
| Official Name | GTP cyclohydrolase I feedback regulator [Source:RGD Symbol;Acc:621746] |
| Ensembl ID | ENSRNOG00000012290 |
| Bio databases IDs | |
| Aliases | GTP cyclohydrolase I feedback regulator |
| Synonyms | 2010323F13RIK, GFRP, GTP cyclohydrolase I feedback regulator, HsT16933, P35 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gchfr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP cyclohydrolase I feedback regulatory protein (GFRP)
- GTP-dependent protein binding
- binding protein
- enzyme inhibitor activity
- enzyme binding
- protein binding
- enzyme regulator activity
- identical protein binding
- amino acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
- melanosomes
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gchfr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of biosynthetic process
- regulation of nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- nuclear membrane
- melanosome
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP cyclohydrolase binding
- protein binding