Gchfr Gene Summary [Mouse]
Enables GTP cyclohydrolase I regulator activity and enzyme inhibitor activity. Involved in negative regulation of small molecule metabolic process. Predicted to be located in dendrite; melanosome; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in dorsal raphe nucleus; medulla oblongata basal plate marginal layer; midbrain mantle layer; and pons marginal layer. Orthologous to human GCHFR (GTP cyclohydrolase I feedback regulator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gchfr |
| Official Name | GTP cyclohydrolase I feedback regulator [Source:MGI Symbol;Acc:MGI:2443977] |
| Ensembl ID | ENSMUSG00000046814 |
| Bio databases IDs | |
| Aliases | GTP cyclohydrolase I feedback regulator |
| Synonyms | 2010323F13RIK, GFRP, GTP cyclohydrolase I feedback regulator, HsT16933, P35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gchfr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP cyclohydrolase I feedback regulatory protein (GFRP)
- GTP-dependent protein binding
- binding protein
- enzyme inhibitor activity
- enzyme binding
- protein binding
- enzyme regulator activity
- identical protein binding
- amino acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
- melanosomes
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gchfr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of biosynthetic process
- regulation of nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- nuclear membrane
- melanosome
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP cyclohydrolase binding
- protein binding