Hbs1l Gene Summary [Rat]
Predicted to enable GTPase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, no-go decay and rescue of stalled ribosome. Predicted to be located in cytoplasm. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytosolic ribosome. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hbs1l |
| Official Name | HBS1-like translational GTPase [Source:RGD Symbol;Acc:1308509] |
| Ensembl ID | ENSRNOG00000014531 |
| Bio databases IDs | |
| Aliases | HBS1-like translational GTPase |
| Synonyms | 2810035F15Rik, EF-1a, eRF3c, ERFS, HBS1, Hbs1-like (S. cerevisiae), HBS1-like translational GTPase, HSPC276 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hbs1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Elongation factor Tu C-terminal domain
- GTPase
- protein binding
- Elongation factor Tu domain 2
- translation regulator
- GTP binding
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- sulfate adenylyltransferase, large subunit
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- small GTP-binding protein domain
- HBS1 N-terminus
- translation elongation factor TU
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign prostatic hyperplasia
- Hodgkin lymphoma
- androgenic alopecia
- coronary artery disease
- hematological disorder
- hypercholesterolemia
- hypothyroidism
- osteoarthropathy
- autosomal dominant thrombocytopenia type 4
- Hodgkin disease
regulates
- Fetal hemoglobin
- gamma globin
role in cell
- expression in
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hbs1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- rescue of stalled ribosome
- signal transduction
- ribosome disassembly
- nuclear-transcribed mRNA catabolic process, no-go decay
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosolic ribosome
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- translation elongation factor activity
- GTPase activity