Gch1

Enables several functions, including GTP binding activity; GTP cyclohydrolase I activity; and metal ion binding activity. Involved in several processes, including dihydrobiopterin metabolic process; negative regulation of cellular senescence; and regulation of apoptotic process. Located in mitochondrion and nucleus. Part of intracellular protein-containing complex. Used to study Parkinsonism; cerebral infarction; hypertension; myocardial infarction; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); liver disease (multiple); middle cerebral artery infarction; pulmonary fibrosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gch1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Gch1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Gch1 gene, providing context for its role in the cell.