Gtf2h4 Gene Summary [Rat]
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. Orthologous to human GTF2H4 (general transcription factor IIH subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Gtf2h4 |
| Official Name | general transcription factor 2H subunit 4 [Source:RGD Symbol;Acc:1303309] |
| Ensembl ID | ENSRNOG00000000831 |
| Bio databases IDs | |
| Aliases | general transcription factor 2H subunit 4 |
| Synonyms | BTF2 p52, general transcription factor 2H subunit 4, general transcription factor II H, polypeptide 4, general transcription factor IIH subunit 4, p52, TFB2, TFIIH, TFIIH4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gtf2h4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor Tfb2
- transcription regulator
- Transcription factor Tfb2 (p52) C-terminal domain
- protein binding
- zinc finger domain
- general RNA polymerase II transcription factor
Pathways
Biological processes and signaling networks where the Gtf2h4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- inguinal hernia
- cervical intraepithelial neoplasia
- lung squamous cell carcinoma
- squamous cell lung cancer
- androgenic alopecia
- sarcoidosis
- multiple sclerosis
- non-small cell lung carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gtf2h4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- transcription from RNA polymerase II promoter
- nucleotide-excision repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- nuclear speck
- core TFIIH complex
- core TFIIH complex portion of holo TFIIH complex
- holo TFIIH complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- general RNA polymerase II transcription factor activity
- double-stranded DNA binding
- ATPase activator activity