S100a4 Gene Summary [Rat]
Enables actin binding activity; calcium ion binding activity; and calcium-dependent protein binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in extracellular space; nucleus; and perinuclear region of cytoplasm. Orthologous to human S100A4 (S100 calcium binding protein A4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | S100a4 |
| Official Name | S100 calcium-binding protein A4 [Source:RGD Symbol;Acc:3245] |
| Ensembl ID | ENSRNOG00000011821 |
| Bio databases IDs | |
| Aliases | S100 calcium-binding protein A4 |
| Synonyms | 18A2, 42A, CAPL, FSP1, metastasin, MTS1, P9KA, PEL98, pk9a, Placental Calcium-Binding, RNP9KA, S100 calcium-binding protein A4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat S100a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- calcium-dependent protein binding
- S-100/ICaBP type calcium binding domain
- dimerization domain
- binding protein
- chemoattractant
- actin binding
- calcium ion binding
- EFh
- protein binding
- receptor binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- urogenital cancer
- cancer
- metastasis
- metastatic colorectal cancer
- adenoma formation
- liver neoplasia
- benign neoplasia
role in cell
- proliferation
- cell viability
- phosphorylation in
- apoptosis
- activation in
- growth
- migration
- expression in
- stabilization in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- Nucleus
- cytosol
- plasma membrane projections
- nucleoplasm
- perinuclear space
- nucleoli
- actin stress fibers
- cell membrane leading edge
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat S100a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- epithelial to mesenchymal transition
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transition metal ion binding
- identical protein binding
- RNA binding
- protein binding
- actin binding
- calcium ion binding
- calcium-dependent protein binding
- chemoattractant activity
- RAGE receptor binding