Lss Gene Summary [Rat]
Predicted to enable identical protein binding activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within actin polymerization or depolymerization; positive regulation of cAMP-dependent protein kinase activity; and positive regulation of cAMP/PKA signal transduction. Predicted to be located in cytoplasm. Predicted to be active in centrosome and sperm head-tail coupling apparatus. Orthologous to human SPATC1L (spermatogenesis and centriole associated 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lss |
| Official Name | lanosterol synthase [Source:RGD Symbol;Acc:620955] |
| Ensembl ID | ENSRNOG00000054549 |
| Bio databases IDs | |
| Aliases | lanosterol synthase |
| Synonyms | 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE, 2810025N20Rik, APMR4, CTRCT44, D10Ertd116e, HYPT14, LANOSTEROL CYCLASE, LANOSTEROL SYNTHASE, LOC103690153, OSC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lss often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prenyltransferase and squalene oxidase repeat
- ISOPREN_C2_like
- Squalene-hopene cyclase C-terminal domain
- squalene/oxidosqualene cyclases
- lanosterol synthase
- squalene-hopene cyclase
- 2,3-oxidosqualene cyclase
- squalene--tetrahymanol cyclase
- enzyme
- protein binding
- Squalene-hopene cyclase N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- epithelial cancer
- cataract 44
- tinea corporis
- tinea pedis
- tinea versicolor
- Alzheimer disease
- alopecia-mental retardation syndrome type 4
- hereditary disorder
- hypotrichosis type 14
role in cell
- survival
- regrowth in
- regrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- lipid droplets
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lss gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- cholesterol biosynthetic process
- steroid biosynthetic process
- triterpenoid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- lanosterol synthase activity