Ldhb Gene Summary [Rat]
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 9. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | Ldhb |
| Official Name | lactate dehydrogenase B [Source:RGD Symbol;Acc:2997] |
| Ensembl ID | ENSRNOG00000013000 |
| Bio databases IDs | |
| Aliases | lactate dehydrogenase B |
| Synonyms | HEL-S-281, H-Ldh, lactate dehydrogenase B, -lactate dehydrogenase h-chain, LDH2, LDHBD, LDH-H, LDH heart subunit, L-lactate dehydrogenase B chain, TRG-5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ldhb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD or NADH binding
- kinase binding
- L-lactate dehydrogenase
- lactate/malate dehydrogenase, NAD binding domain
- enzyme
- lactate/malate dehydrogenase, alpha/beta C-terminal domain
- protein binding
- identical protein binding
- lactate dehydrogenase
- malate dehydrogenase, NAD-dependent
Pathways
Biological processes and signaling networks where the Ldhb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- androgenic alopecia
- lactate dehydrogenase B deficiency
- rheumatoid arthritis
- organismal death
- rotator cuff injury
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- production in
- downregulation in
- upregulation in
- glycolysis in
- mitochondrial respiration in
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Nucleus
- cytosol
- mitochondrial inner membrane
- synaptic vesicles
- membrane rafts
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ldhb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- NAD metabolic process
- lactate metabolic process
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane raft
- membrane
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- L-lactate dehydrogenase activity
- NAD binding
- kinase binding