Cacna1d Gene Summary [Rat]
Enables PDZ domain binding activity; ankyrin binding activity; and high voltage-gated calcium channel activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of CREB transcription factor activity; and positive regulation of transport. Located in several cellular components, including dendrite; perikaryon; and sarcolemma. Is active in postsynaptic membrane. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna1d |
| Official Name | calcium voltage-gated channel subunit alpha1 D [Source:RGD Symbol;Acc:70973] |
| Ensembl ID | ENSRNOG00000013147 |
| Bio databases IDs | |
| Aliases | calcium voltage-gated channel subunit alpha1 D |
| Synonyms | 8430418G19Rik, CACH3, CACN4, CACNL1A2, calcium channel, voltage-dependent, L type, alpha 1D subunit, calcium channel, voltage-dependent, L type, α 1D subunit, calcium voltage-gated channel subunit alpha1 D, Cav1.3, Cav1.3 alpha1, Cchl1a, CCHL1A2, D-LTCC, Ltcc cav1.3, L-type calcium channedl α 1d subunit, L type VOLTAGE DEPENDENT CALCIUM CHANNEL alpha 1.3, L type VOLTAGE DEPENDENT CALCIUM CHANNEL α 1.3, PASNA, SANDD, VDCC alpha 1D, VDCC α 1D |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cacna1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage-dependent L-type calcium channel, IQ-associated
- intracellular loop
- synprint domain
- Ion transport protein
- calcium channel
- high voltage-gated calcium channel
- actinin binding
- protein binding
- Voltage-gated calcium channel subunit alpha, C-term
- ion channel
- PDZ-domain binding
- voltage-gated calcium channel
- Voltage gated calcium channel IQ domain
- ankyrin binding
- cytoplasmic loop
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Cacna1d gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- PKCθ Signaling in T Lymphocytes
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GABBR2
- nisoldipine
- isradipine
- nicardipine
- amlodipine
- nitrendipine
- felodipine
- bepridil
- nifedipine
- verapamil
disease
- adenoma formation
- heart failure
- chronic kidney disease
- atrial fibrillation
- ischemic cardiomyopathy
- non-insulin-dependent diabetes mellitus
- dementia
- disorder of coronary artery
- acute coronary syndrome
- unstable angina
role in cell
- proliferation
- migration
- activation in
- exocytosis by
- function
- differentiation
- abnormal morphology
- number
- degeneration
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- perinuclear region
- cellular membrane
- apical membrane
- presynaptic membrane
- somatic membrane
- postsynaptic membrane
- basolateral membrane
- neurofilaments
- nerve ending
- dendrite initial segments
- sarcolemma
- Z line
- perikaryon
- dendrites
- ribbon synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cacna1d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane depolarization involved in regulation of SA node cardiac muscle cell action potential
- regulation of cardiac muscle cell action potential involved in contraction
- calcium ion import
- membrane depolarization involved in regulation of cardiac muscle cell action potential
- regulation of atrial cardiomyocyte membrane repolarization
- positive regulation of calcium ion transport
- positive regulation of adenylate cyclase activity
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- sensory perception of sound
- calcium ion transport
- calcium ion transmembrane transport
- regulation of heart rate by cardiac conduction
Cellular Component
Where in the cell the gene product is active
- Z disc
- voltage-gated calcium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- high voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in regulation of cardiac muscle cell action potential
- ankyrin binding
- metal ion binding
- voltage-gated calcium channel activity involved in regulation of SA node cardiac muscle cell action potential
- calcium channel activity
- alpha-actinin binding
- voltage-gated calcium channel activity