Gabbr2 Gene Summary [Rat]
Enables G protein-coupled GABA receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; and neuron-glial cell signaling. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Biomarker of nicotine dependence. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabbr2 |
| Official Name | gamma-aminobutyric acid type B receptor subunit 2 [Source:RGD Symbol;Acc:619864] |
| Ensembl ID | ENSRNOG00000008431 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid type B receptor subunit 2 |
| Synonyms | DEE59, EIEE59, Gaba B2, GABABR2, GABA(B)R2, gamma-aminobutyric acid type B receptor subunit 2, Gb2, Gm425, GPR51, GPRC3B, HG20, HRIHFB2099, NDPLHS, γ-aminobutyric acid type B receptor subunit 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gabbr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Periplasmic binding protein
- GABA-B receptor
- Receptor family ligand binding region
- intracellular loop
- coiled-coil domain
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
- Type 1 periplasmic binding fold superfamily
- Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain
- cytosolic tail domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Gabbr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- muscle spasticity
- schizophrenia
- hiccup
- spinal cord disorder
- early infantile epileptic encephalopathy type 59
- peripheral neuropathy
- multiple sclerosis
- depressive disorder
- pervasive developmental disorder
- neurodevelopmental disorder with poor language and loss of hand skills
role in cell
- expression in
- quantity
- degradation in
- accumulation in
- cisplatin sensitivity
- autophagy in
- inhibitory postsynaptic potential
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi-enriched fraction
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- cytoplasmic aggregates
- cytosol
- cytoplasmic face of plasma membrane
- presynaptic membrane
- postsynaptic membrane
- neurites
- synaptosomes
- synapse
- membrane processes
- perikaryon
- endoplasmic reticulum-rich vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gabbr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- negative regulation of adenylate cyclase activity
- G-protein coupled receptor signaling pathway
- synaptic transmission
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- G-protein coupled receptor heterodimeric complex
- postsynaptic membrane
- cytoplasm
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- G-protein coupled GABA receptor activity
- protein binding
- protein heterodimerization activity