Mvd Gene Summary [Rat]
Enables diphosphomevalonate decarboxylase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and response to xenobiotic stimulus. Located in peroxisomal matrix. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mvd |
| Official Name | mevalonate diphosphate decarboxylase [Source:RGD Symbol;Acc:621292] |
| Ensembl ID | ENSRNOG00000013376 |
| Bio databases IDs | |
| Aliases | mevalonate diphosphate decarboxylase |
| Synonyms | diphosphomevalonate decarboxylase, Erg19, FP17780, MDDase, mevalonate diphosphate decarboxylase, mevalonate (diphospho) decarboxylase, MEVALONATE PYROPHOSPHATE DECARBOXYLASE, MPD, Mvpd, POROK7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mvd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]
- Hsp70 protein binding
- diphosphomevalonate decarboxylase
- Mevalonate 5-diphosphate decarboxylase C-terminal domain
- protein homodimerization
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- multiple types porokeratosis type 7
- linear porokeratosis
- chronic kidney disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- polycystic ovary syndrome
- colon carcinoma
- colon epithelial cancer
role in cell
- expression in
- proliferation
- activation in
- growth
- bacterial burden
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mvd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- isopentenyl diphosphate biosynthetic process, mevalonate pathway
- positive regulation of cell proliferation
- cholesterol biosynthetic process
- isoprenoid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein homodimerization activity
- diphosphomevalonate decarboxylase activity
- Hsp70 protein binding