Pgap1 Gene Summary [Rat]
Enables phosphatidylinositol deacylase activity. Involved in GPI anchor biosynthetic process and positive regulation of ER to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. Orthologous to human PGAP1 (post-GPI attachment to proteins inositol deacylase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgap1 |
| Official Name | post-GPI attachment to proteins inositol deacylase 1 [Source:RGD Symbol;Acc:1303213] |
| Ensembl ID | ENSRNOG00000013388 |
| Bio databases IDs | |
| Aliases | post-GPI attachment to proteins inositol deacylase 1 |
| Synonyms | 5033403E17Rik, 9030223K07Rik, A530084K22, Bst1, D230012E17RIK, ISPD3024, MRT42, NEDDSBA, oto, post-GPI attachment to proteins 1, post-GPI attachment to proteins inositol deacylase 1, SPG67 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pgap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolase fold
- alpha/beta hydrolases
- phosphatidylinositol deacylase
- enzyme
- ester bond hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- lipopolysaccharide
- tetradecanoylphorbol acetate
- mir-223
- Gstp1 (includes others)
- NEAT1
- ANGPT2
disease
- systemic lupus erythematosus
- diabetes mellitus
- autosomal recessive mental retardation type 42
- small cell lung cancer
- hereditary disorder
- osteoarthritis
- systemic autoimmune syndrome
- growth failure
- otocephaly
- pemphigus foliaceus
role in cell
- apoptosis
- G1 phase
- S phase
- secretion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pgap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- GPI anchor metabolic process
- anterior/posterior axis specification
- ER to Golgi vesicle-mediated transport
- embryonic pattern specification
- protein transport
- attachment of GPI anchor to protein
- forebrain regionalization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on ester bonds
- phosphatidylinositol deacylase activity