Phgdh Gene Summary [Rat]
Enables phosphoglycerate dehydrogenase activity. Predicted to be involved in L-serine biosynthetic process. Predicted to act upstream of or within several processes, including gamma-aminobutyric acid metabolic process; nervous system development; and proteinogenic amino acid metabolic process. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phgdh |
| Official Name | phosphoglycerate dehydrogenase [Source:RGD Symbol;Acc:61987] |
| Ensembl ID | ENSRNOG00000019328 |
| Bio databases IDs | |
| Aliases | phosphoglycerate dehydrogenase |
| Synonyms | 3-PGDH, 3-phosphoglycerate dehydrogenase, 4930479N23, A10, HEL-S-113, LOC105378936, NLS, NLS1, PDG, PGAD, PGD, PGDH, PGDH3, PHGDHD, phosphoglycerate dehydrogenase, SERA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Phgdh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- electron carrier
- D-3-phosphoglycerate dehydrogenase
- enzyme
- protein binding
- D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
- phosphoglycerate dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- latent tuberculosis
- epithelial cancer
- cancer
- metastasis
- Neu-Laxova syndrome type 1
- phosphoglycerate dehydrogenase deficiency
- gout
- idiopathic pulmonary fibrosis
- hypoplasia
role in cell
- survival
- apoptosis
- growth
- cell viability
- binding in
- production in
- expression in
- proliferation
- synthesis in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- actin bundles
- cytosol
- mitochondrial inner membrane
- cytoplasmic droplets
- membrane processes
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Phgdh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- neuron projection development
- glutamine metabolic process
- L-serine biosynthetic process
- brain development
- glial cell development
- gamma-aminobutyric acid metabolic process
- spinal cord development
- glycine metabolic process
- threonine metabolic process
- regulation of gene expression
- G1 to G0 transition
- taurine metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- L-malate dehydrogenase activity
- NAD binding
- electron carrier activity
- phosphoglycerate dehydrogenase activity