Atp6v0a4 Gene Summary [Rat]
Predicted to enable ATPase binding activity. Predicted to be involved in several processes, including sensory perception of sound; synaptic vesicle lumen acidification; and vacuolar acidification. Predicted to act upstream of or within proton transmembrane transport. Located in apical plasma membrane. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v0a4 |
| Official Name | ATPase H+ transporting V0 subunit a4 [Source:RGD Symbol;Acc:1305055] |
| Ensembl ID | ENSRNOG00000013428 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting V0 subunit a4 |
| Synonyms | A4, ATP6N1B, ATP6N2, Atp6v0a4 predicted, ATPase, H+ transporting, lysosomal V0 subunit A4, ATPase H+ transporting V0 subunit a4, DRTA3, RDRTA2, RTA1C, RTADR, STV1, V-ATPase alpha4, VPH1, VPP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6v0a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- basic amino acid motif
- H+-transporting two-sector ATPase
- protein binding
- H+-exporting ATPase
- V-type ATPase 116kDa subunit family
- transporter
Pathways
Biological processes and signaling networks where the Atp6v0a4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive distal renal tubular acidosis
- distal renal tubular acidosis type 3 with or without sensorineural hearing loss
- renal clear cell adenocarcinoma
- renal clear cell cancer
- organismal death
- distal renal tubular acidosis
- hereditary disorder
- distal renal tubular acidosis type 3 without sensorineural hearing loss
- renal tubular acidosis
- keratocystic odontogenic tumor
role in cell
- migration
- binding in
- invasion by
- ossification by
- localization in
- pH
- acidification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- synaptic vesicle membrane
- apical compartment
- cellular membrane
- Plasma Membrane
- endosomes
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- endosomal membrane
- brush border
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6v0a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal tubular secretion
- sensory perception of sound
- intracellular pH reduction
- ossification
- vacuolar acidification
- regulation of pH
Cellular Component
Where in the cell the gene product is active
- proton-transporting V-type ATPase complex
- lysosomal membrane
- plasma membrane
- vacuolar proton-transporting V-type ATPase, V0 domain
- endosome
- brush border membrane
- extracellular vesicular exosome
- apical part of cell
- vacuolar proton-transporting V-type ATPase complex
- phagocytic vesicle membrane
- endosome membrane
- synaptic vesicle membrane
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism
- ATPase binding