Cela2a Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including insulin catabolic process; regulation of insulin secretion; and regulation of platelet aggregation. Predicted to be located in extracellular region and keratohyalin granule. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 4. Orthologous to several human genes including CELA2A (chymotrypsin like elastase 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cela2a |
| Official Name | chymotrypsin like elastase 2A [Source:RGD Symbol;Acc:2548] |
| Ensembl ID | ENSRNOG00000013628 |
| Bio databases IDs | |
| Aliases | chymotrypsin like elastase 2A |
| Synonyms | AOMS4, Cela2, chymotrypsin like elastase 2A, chymotrypsin-like elastase family, member 2A, Ela-2, ELA2A, ELAII, Elaii1, Elastase2, PANCREATIC ELASTASE2A, PE-1, RP23-395H4.4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cela2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- endopeptidase
- serine endopeptidase
- trypsin
- Tryp_SPc
- peptidase
- serine hydrolase
- protein binding
Pathways
Biological processes and signaling networks where the Cela2a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- prostate cancer
- abdominal obesity-metabolic syndrome 4
- prostatic carcinoma
- impotence
- alcoholic pancreatitis
- pulmonary emphysema
role in cell
- accumulation
- apoptosis
- transcription in
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- granules
- cytosol
- nuclear envelope
- keratohyalin granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cela2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion
- response to insulin stimulus
- proteolysis
- regulation of platelet aggregation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine hydrolase activity
- endopeptidase activity
- serine-type endopeptidase activity