Klk5 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including amelogenesis; extracellular matrix disassembly; and positive regulation of antibacterial peptide production. Predicted to be located in epidermal lamellar body. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK5 (kallikrein related peptidase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klk5 |
| Official Name | kallikrein related-peptidase 5 [Source:RGD Symbol;Acc:1593461] |
| Ensembl ID | ENSRNOG00000018831 |
| Bio databases IDs | |
| Aliases | kallikrein related-peptidase 5 |
| Synonyms | 1110030O19RIK, kallikrein related-peptidase 5, KLK-L2, SCTE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klk5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- serine-type peptidase
- peptidase
- protein binding
Pathways
Biological processes and signaling networks where the Klk5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- pruritus
- atopic dermatitis
- erythroderma
- serous ovarian cancer
role in cell
- phosphorylation in
- cellular infiltration by
- activation in
- migration
- adhesion
- dispersal
- wound closure by
- molecular cleavage in
- epithelial-mesenchymal transition
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cytosol
- alveolar epithelial lamellar bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klk5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- proteolysis
- positive regulation of antibacterial peptide production
- epidermis development
- cornification
- amelogenesis
- positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule
- cytosol
- epidermal lamellar body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity
- peptidase activity