CELA2A
CELA2A Gene Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]
Details
| Type | Processed Transcript |
| Official Symbol | CELA2A |
| Official Name | chymotrypsin like elastase 2A [Source:HGNC Symbol;Acc:HGNC:24609] |
| Ensembl ID | ENSG00000142615 |
| Bio databases IDs | |
| Aliases | chymotrypsin like elastase 2A, elastase 2A |
| Synonyms | AOMS4,Cela2,chymotrypsin like elastase 2A,chymotrypsin-like elastase family, member 2A,Ela-2,ELA2A,ELAII,Elaii1,Elastase2,PANCREATIC ELASTASE2A,PE-1,RP23-395H4.4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- endopeptidase
- serine endopeptidase
- trypsin
- Tryp_SPc
- peptidase
- serine hydrolase
- protein binding
Pathways
Biological processes and signaling networks where the CELA2A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CEBPA
- ATG9A
- ARID3B
- SMAD4
- CDKN1A
- MAS1
- UFD1
- DNAJB4
- HGS
- SARM1
disease
- epithelial cancer
- neoplasia
- prostate cancer
- abdominal obesity-metabolic syndrome 4
- prostatic carcinoma
- impotence
- alcoholic pancreatitis
- pulmonary emphysema
regulated by
- GFI1
- AHR
- CDKN1A
- carbon tetrachloride
- KLK5
- GATA2
- AGT
- L-triiodothyronine
- SERPINB1
- mesenchymal stem cells
regulates
- synthetic promoter
- MMP9
- insulin
- TFPI
- Collagen type IV
- CDKN2A
- CAT reporter gene
- insulin (complex)
- COL17A1
- fibrillin
role in cell
- accumulation
- apoptosis
- transcription in
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- granules
- cytosol
- nuclear envelope
- keratohyalin granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CELA2A gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of insulin secretion
- response to insulin stimulus
- proteolysis
- regulation of platelet aggregation
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- serine hydrolase activity
- endopeptidase activity
- serine-type endopeptidase activity