Skor1 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Predicted to be involved in negative regulation of BMP signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in dendrite and neuronal cell body. Predicted to be part of transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKOR1 (SKI family transcriptional corepressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Skor1 |
| Official Name | SKI family transcriptional corepressor 1 [Source:RGD Symbol;Acc:1307687] |
| Ensembl ID | ENSRNOG00000013959 |
| Bio databases IDs | |
| Aliases | SKI family transcriptional corepressor 1 |
| Synonyms | AV273001, C230094B15Rik, CORL1, FUSSEL15, LBXCOR1, RGD1307687, SKI family transcriptional corepressor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Skor1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- polo kinase kinase
- transcription regulator
- double-stranded DNA binding
- SKI/SNO/DAC family
- protein binding
- c-SKI Smad4 binding domain
- sequence-specific DNA binding
- DHD_Ski_Sno_Dac
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Skor1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- transcription factor complex
- cytoplasm
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- SMAD binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity