SKOR1 Gene Summary [Human]
Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of BMP signaling pathway. Located in dendrite and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SKOR1 |
| Official Name | SKI family transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:21326] |
| Ensembl ID | ENSG00000188779 |
| Bio databases IDs | |
| Aliases | SKI family transcriptional corepressor 1, transcriptional corepressor CORL1, functional smad suppressing element 15, corepressor for LBX1 |
| Synonyms | AV273001, C230094B15Rik, CORL1, FUSSEL15, LBXCOR1, RGD1307687, SKI family transcriptional corepressor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SKOR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- polo kinase kinase
- transcription regulator
- double-stranded DNA binding
- SKI/SNO/DAC family
- protein binding
- c-SKI Smad4 binding domain
- sequence-specific DNA binding
- DHD_Ski_Sno_Dac
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SKOR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- transcription factor complex
- cytoplasm
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- SMAD binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity