Npy5r Gene Summary [Rat]
Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including generation of ovulation cycle rhythm; negative regulation of GABAergic synaptic transmission; and regulation of acute inflammatory response. Predicted to be located in membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; neuron projection; and presynapse. Used to study absence epilepsy and hyperinsulinism. Biomarker of coronary restenosis; obesity; and prolactinoma. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npy5r |
| Official Name | neuropeptide Y receptor Y5 [Source:RGD Symbol;Acc:3199] |
| Ensembl ID | ENSRNOG00000014172 |
| Bio databases IDs | |
| Aliases | neuropeptide Y receptor Y5 |
| Synonyms | neuropeptide Y receptor Y5, NPYR5, NPYY5-R, Npy Y5 Receptor, Y5, Y5R, Y5 receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Npy5r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- peptide YY receptor
- pancreatic polypeptide receptor
- neuropeptide Y receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Npy5r gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyslipidemia
- obesity
- limbic seizure
- adult-onset obesity
role in cell
- apoptosis
- proliferation
- production in
- maturation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- cellular membrane
- neurites
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Npy5r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of ovulation cycle rhythm
- G-protein coupled receptor signaling pathway
- outflow tract morphogenesis
- synaptic transmission
- negative regulation of glutamate secretion
- eating behavior
- cardiac left ventricle morphogenesis
- positive regulation of acute inflammatory response
- positive regulation of smooth muscle cell proliferation
- neuropeptide signaling pathway
- negative regulation of synaptic transmission, GABAergic
- negative regulation of acute inflammatory response to antigenic stimulus
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
Cellular Component
Where in the cell the gene product is active
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- peptide YY receptor activity
- pancreatic polypeptide receptor activity
- neuropeptide Y receptor activity