Asns Gene Summary [Rat]
Enables asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and response to aldosterone. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma and retinal degeneration. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asns |
| Official Name | asparagine synthetase (glutamine-hydrolyzing) [Source:RGD Symbol;Acc:2162] |
| Ensembl ID | ENSRNOG00000007546 |
| Bio databases IDs | |
| Aliases | asparagine synthetase (glutamine-hydrolyzing) |
| Synonyms | AS, ASNSD, Asparagine synthetase, asparagine synthetase (glutamine-hydrolyzing), Aspartic acid synthase, TS11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Asns often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- asparagine synthase (glutamine-hydrolyzing)
- Glutamine amidotransferase domain
- Asparagine synthase
- enzyme
- protein binding
- asparagine synthase (glutamine-hydrolysing)
- identical protein binding
- Gn_AT_II
- Adenine nucleotide alpha hydrolase (AANH) superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- glioblastoma
- glioblastoma cancer
- asparagine synthetase deficiency
- hereditary disorder
- colon adenocarcinoma
- colon epithelial cancer
- Goodpasture syndrome
- autosomal recessive spinocerebellar ataxia type 29
role in cell
- proliferation
- growth
- expression in
- migration
- apoptosis
- colony formation by
- response by
- stabilization in
- cell survival
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Asns gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-asparagine biosynthetic process
- negative regulation of apoptotic process
- asparagine biosynthetic process
- glutamine metabolic process
- cellular response to glucose starvation
- positive regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- asparagine synthase (glutamine-hydrolyzing) activity