Cdh13 Gene Summary [Rat]
Predicted to enable several functions, including adiponectin binding activity; beta-catenin binding activity; and low-density lipoprotein particle binding activity. Involved in cellular response to toxic substance and cellular response to xenobiotic stimulus. Located in perinuclear region of cytoplasm. Is active in GABA-ergic synapse. Used to study substance-related disorder. Biomarker of coronary restenosis. Human ortholog(s) of this gene implicated in breast cancer (multiple); lung non-small cell carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human CDH13 (cadherin 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdh13 |
| Official Name | cadherin 13 [Source:RGD Symbol;Acc:619745] |
| Ensembl ID | ENSRNOG00000014371 |
| Bio databases IDs | |
| Aliases | cadherin 13 |
| Synonyms | 4932416G01Rik, CADHERIN 13, CDHH, Cdht, H-cadherin, Heart-cadherin, P105, T-CAD, T-CADHERIN, Truncated-cadherin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdh13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Bacterial cadherin-like domain
- hormone binding
- binding protein
- Cadherin prodomain like
- Cadherin repeat-like domain
- cadherin binding
- protein binding
- low-density lipoprotein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Cdh13 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- hypertension
- heart disease
- Alzheimer disease
- schizophrenia
- uterine serous papillary cancer
- coronary artery disease
- scarlet fever
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- growth
- proliferation
- phosphorylation in
- survival
- quantity
- formation
- migration
- invasion by
- endocytosis by
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- cell-cell contacts
- plasma membrane extracellular face
- caveolae
- neurites
- synapse
- sarcolemma
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdh13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- low-density lipoprotein particle mediated signaling
- adherens junction organization
- multicellular organismal development
- negative regulation of cell proliferation
- sprouting angiogenesis
- regulation of epidermal growth factor receptor signaling pathway
- homophilic cell adhesion
- endothelial cell migration
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of calcium-mediated signaling
- positive regulation of smooth muscle cell proliferation
- regulation of endocytosis
- localization within membrane
- cell migration
- calcium-dependent cell-cell adhesion
- keratinocyte proliferation
- cell-cell junction assembly
- cell morphogenesis
- negative regulation of cell adhesion
- positive regulation of positive chemotaxis
- Rho protein signal transduction
- positive regulation of cell-matrix adhesion
- cell-cell adhesion mediated by cadherin
- lamellipodium assembly
- positive regulation of endothelial cell proliferation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- neuron projection
- plasma membrane
- extracellular space
- adherens junction
- caveola
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- catenin complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding
- cadherin binding
- adiponectin binding
- beta-catenin binding
- lipoprotein particle binding
- low-density lipoprotein particle binding