Gpm6a Gene Summary [Rat]
Enables calcium channel activity. Involved in positive regulation of filopodium assembly; regulation of synapse organization; and synapse assembly. Located in several cellular components, including filopodium; neuron projection; and neuronal cell body. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone membrane. Orthologous to human GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpm6a |
| Official Name | glycoprotein m6a [Source:RGD Symbol;Acc:631368] |
| Ensembl ID | ENSRNOG00000010731 |
| Bio databases IDs | |
| Aliases | glycoprotein m6a |
| Synonyms | glycoprotein M6A, GPM6, M6A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpm6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium channel
- protein binding
- Myelin proteolipid protein (PLP or lipophilin)
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- post-traumatic stress disorder
- hepatocellular carcinoma
- organismal death
- schizophrenia
- epithelial cancer
- uterine leiomyoma
- leiomyomatosis
- liver cancer
- uterine serous papillary cancer
role in cell
- cell death
- quantity
- migration
- outgrowth
- formation
- differentiation
- assembly
- density
- organization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- presynaptic regions
- cell surface
- cellular membrane
- presynaptic membrane
- growth cone
- neurites
- filopodia
- perikaryon
- axons
- dendrites
- mossy fiber boutons
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpm6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- response to bacterium
- synapse assembly
- stem cell differentiation
- regulation of synapse organization
- neuron projection development
- neural retina development
- calcium ion transmembrane transport
- neuron projection morphogenesis
- positive regulation of filopodium assembly
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- axonal growth cone
- dendritic spine
- filopodium
- presynaptic active zone membrane
- neuronal cell body
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium channel activity