Anxa5 Gene Summary [Rat]
Enables several functions, including P-type calcium transporter activity; calcium-dependent phospholipid binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to lead ion; and negative regulation of prolactin secretion. Located in several cellular components, including Z disc; intercalated disc; and perikaryon. Is active in synaptic vesicle membrane. Biomarker of several diseases, including Wilson disease; cryptorchidism; glomerulonephritis; hyperthyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; myocardial infarction; and systemic scleroderma. Orthologous to human ANXA5 (annexin A5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anxa5 |
| Official Name | annexin A5 [Source:RGD Symbol;Acc:2120] |
| Ensembl ID | ENSRNOG00000014453 |
| Bio databases IDs | |
| Aliases | annexin A5 |
| Synonyms | ANAV, Annexin A5, Annexin V, ANX5, CPB-I, ENX2, HEL-S-7, LC5, PP4, RPRGL3, VAC-alph |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Anxa5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- core domain, structural
- Ca2+-transporting ATPase
- calcium-dependent phospholipid binding
- protein binding
- identical protein binding
- polypeptide hormone binding
- binding protein
- receptor tyrosine kinase binding
- phospholipase inhibitor
- gamma-PKC homology domain
- Annexin
- transporter
Pathways
Biological processes and signaling networks where the Anxa5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial cancer
- liver cancer
- colorectal cancer
- hepatitis B virus-related hepatocellular carcinoma
- hypertensive heart disease
- experimentally-induced diabetes
- metastasis
- pervasive developmental disorder
- organismal death
role in cell
- expression in
- cell viability
- formation
- cell death
- apoptosis
- phosphorylation in
- binding
- migration
- fusion
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- caveolae-derived endocytic vesicles
- endothelial microparticle
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- membrane surface
- Nucleus
- Golgi Apparatus
- intercellular junctions
- cytosol
- plasma membrane extracellular face
- outer leaflet
- nuclear envelope
- synaptic vesicles
- sarcolemma
- Z line
- membrane rafts
- cellular protrusions
- perikaryon
- dendrites
- axon terminals
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Anxa5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of coagulation
- signal transduction
- negative regulation of apoptotic process
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- vesicle membrane
- endothelial microparticle
- sarcolemma
- membrane
- external side of plasma membrane
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- protein binding
- calcium ion binding
- phospholipase inhibitor activity
- phospholipid binding
- calcium-dependent phospholipid binding