Cct3 Gene Summary [Rat]
Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone mediated protein folding independent of cofactor; positive regulation of protein localization to Cajal body; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in cell body and microtubule. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT3 (chaperonin containing TCP1 subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cct3 |
| Official Name | chaperonin containing TCP1 subunit 3 [Source:RGD Symbol;Acc:735038] |
| Ensembl ID | ENSRNOG00000019090 |
| Bio databases IDs | |
| Aliases | chaperonin containing TCP1 subunit 3 |
| Synonyms | Cct1 γ, CCTG, CCT-gamma, CCT-γ, chaperonin containing TCP1 subunit 3, Chaperonin subunit 3 (gamma), Chaperonin subunit 3 (γ), Matricin, NEDSVH, PIG48, TCP-1-gamma, Tcp1-rs3, TCP-1-γ, TRIC5, TriC-P5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cct3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Alzheimer disease
- non-small cell lung cancer
- organismal death
- Parkinson disease
- heart failure
- bladder cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- Burkitt lymphoma
role in cell
- cell death
- apoptosis
- expression in
- growth
- proliferation
- migration
- invasion by
- accumulation in
- transport in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- cytoskeleton
- cilia
- Nucleus
- microtubules
- cytosol
- nucleoli
- perikaryon
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cct3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein stabilization
- protein folding
Cellular Component
Where in the cell the gene product is active
- chaperonin-containing T-complex
- cytoskeleton
- extracellular vesicular exosome
- cell body
- cytosol
- sperm protein complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- protein binding involved in protein folding
- RNA binding
- unfolded protein binding