Cars2 Gene Summary [Rat]
Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cars2 |
| Official Name | cysteinyl-tRNA synthetase 2, mitochondrial [Source:RGD Symbol;Acc:1311612] |
| Ensembl ID | ENSRNOG00000014526 |
| Bio databases IDs | |
| Aliases | cysteinyl-tRNA synthetase 2, mitochondrial |
| Synonyms | 2310051N18Rik, 2410044A07Rik, COXPD27, cysRS, cysteinyl-tRNA synthetase 2, mitochondrial, D530030H10Rik, LOC105376684, RGD1311612 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cars2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
- cysteinyl-tRNA synthetase
- enzyme
- cysteine-tRNA ligase
- nucleotidyl transferase superfamily
- tRNA synthetases class I (C) catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cars2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cysteinyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- cysteine-tRNA ligase activity