ATP5F1D Gene Summary [Human]
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ATP5F1D |
| Official Name | ATP synthase F1 subunit delta [Source:HGNC Symbol;Acc:HGNC:837] |
| Ensembl ID | ENSG00000099624 |
| Bio databases IDs | |
| Aliases | ATP synthase F1 subunit delta |
| Synonyms | 0610008F14RIK, 1500000I11Rik, ATP5D, Atpase D, ATPD, ATP Synthase F1 Delta, ATP synthase F1 subunit delta, ATP synthase F1 subunit δ, ATP Synthase F1 δ, F1F0 ATPase delta, F1F0 ATPase δ, LOC100910032, LOC687032, LOC690935, MC5DN5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP5F1D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- adenosine-tetraphosphatase
- binding protein
- mitochondrial ATP synthase delta subunit
- ATP synthase, F1 epsilon subunit (delta in mitochondria)
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- ATP synthase, Delta/Epsilon chain, beta-sandwich domain
- structural molecule
- ATPase
- transporter
- alternate F1F0 ATPase, F1 subunit epsilon
Pathways
Biological processes and signaling networks where the ATP5F1D gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- mitochondrial complex V deficiency nuclear type 5
- Waldenström macroglobulinemia
- mitochondrial disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- Huntington disease
- chronic obstructive pulmonary disease
role in cell
- binding in
- glycolysis in
- respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cristae-like membrane
- mitochondrial envelope
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP5F1D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial proton-transporting ATP synthase complex assembly
- response to copper ion
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ADP binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism