Klc1 Gene Summary [Rat]
Enables tubulin binding activity. Involved in intracellular protein transport and protein localization to synapse. Located in several cellular components, including growth cone; neuronal cell body; and vesicle. Part of kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Orthologous to human KLC1 (kinesin light chain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klc1 |
| Official Name | kinesin light chain 1 [Source:RGD Symbol;Acc:621411] |
| Ensembl ID | ENSRNOG00000011572 |
| Bio databases IDs | |
| Aliases | kinesin light chain 1 |
| Synonyms | kinesin light chain 1, KLC, KNS2, KNS2A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MalT-like TPR region
- RXXsL motif
- tubulin binding
- Tetratricopeptide repeats
- type IV pilus biogenesis/stability protein PilW
- coiled-coil domain
- protein binding
- heptad repeat domain
- motor domain
- tetratricopeptide repeat
- motor protein
- YSPTSPS repeat
Pathways
Biological processes and signaling networks where the Klc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- depressive disorder
- schizophrenia
- Alzheimer disease
- breast carcinoma
- breast cancer
- pervasive developmental disorder
- pathogenesis
- gout
- cataract disease
role in cell
- accumulation
- swelling
- transport in
- binding
- degradation
- transport
- disorganization
- localization
- movement by
- deposition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- organelle
- perinuclear region
- cellular membrane
- vesicles
- cytosol
- ciliary rootlet
- growth cone
- neurites
- cytoplasmic vesicles
- perikaryon
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule disassembly
- cell adhesion
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoplasm
- membrane
- cytosol
- cytoplasmic vesicle
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- kinesin binding
- motor activity