Prpf4 Gene Summary [Rat]
Predicted to enable U4 snRNA binding activity and U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type precatalytic spliceosome; U4/U6 snRNP; and U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prpf4 |
| Official Name | pre-mRNA processing factor 4 [Source:RGD Symbol;Acc:1311303] |
| Ensembl ID | ENSRNOG00000014777 |
| Bio databases IDs | |
| Aliases | pre-mRNA processing factor 4 |
| Synonyms | 1600015H11Rik, AW047464, bN189G18.1, HPRP4, HPRP4P, pre-mRNA processing factor 4, pre-mRNA splicing tri-snRNP complex factor PRPF4, PRP4, Prp4p, RP70, SNRNP60, U4/U6-60 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prpf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pre-mRNA processing factor 4 (PRP4) like
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- Splicing Factor Motif, present in Prp18 and Pr04
Pathways
Biological processes and signaling networks where the Prpf4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa type 70
- retinal dystrophy
- major depression
- androgenic alopecia
role in cell
- cell cycle progression
- splicing by
- mitosis
- autophagy in
- transport
- autophagy
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- spliceosomes
- nucleoplasm
- nuclear speckles
- Cajal bodies
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prpf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA splicing
- RNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- U4/U6 x U5 tri-snRNP complex
- U4/U6 snRNP
- Cajal body
- spliceosomal complex
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- U6 snRNA binding
- protein binding
- U4 snRNA binding