Ppih Gene Summary [Rat]
Predicted to enable peptidyl-prolyl cis-trans isomerase activity and ribonucleoprotein complex binding activity. Predicted to be involved in positive regulation of viral genome replication. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of U4/U6 snRNP and U4/U6 x U5 tri-snRNP complex. Orthologous to human PPIH (peptidylprolyl isomerase H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppih |
| Official Name | peptidylprolyl isomerase H [Source:RGD Symbol;Acc:1564921] |
| Ensembl ID | ENSRNOG00000008489 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase H |
| Synonyms | 1100001J08Rik, 2010111B15Rik, 4833408F11Rik, cyclophilin H, CYP-20, CYPH, D4WSU43E, peptidyl prolyl isomerase H, RGD1564921, SnuCyp-20, USA-CYP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppih often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidylprolyl isomerase
- cyclophilin catalytic pocket
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- ribonucleoprotein binding
- cyclosporin A binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ppih gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppih gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- protein peptidyl-prolyl isomerization
- protein folding
- positive regulation of viral genome replication
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- nuclear speck
- U4/U6 x U5 tri-snRNP complex
- U4/U6 snRNP
- spliceosomal complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- ribonucleoprotein complex binding