Stc1 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Involved in several processes, including cellular response to cAMP; decidualization; and embryo implantation. Located in apical plasma membrane. Orthologous to human STC1 (stanniocalcin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stc1 |
| Official Name | stanniocalcin 1 [Source:RGD Symbol;Acc:621776] |
| Ensembl ID | ENSRNOG00000015075 |
| Bio databases IDs | |
| Aliases | stanniocalcin 1 |
| Synonyms | STANNIOCALCIN 1, STC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Stanniocalcin family
- hormone
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tubulo-interstitial fibrosis
- non-small cell lung cancer
- metastasis
- weight gain
- cancer
- dextran sodium sulfate-induced colitis
- Crohn disease
- non-small cell lung carcinoma
- urinary bladder stone
- ovarian cancer
role in cell
- survival
- cell viability
- apoptosis
- phosphorylation in
- accumulation in
- expression in
- proliferation
- invasion by
- migration
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Plasma Membrane
- Mitochondria
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to vitamin D
- signal transduction
- regulation of cardiac muscle cell contraction
- decidualization
- growth plate cartilage axis specification
- embryo implantation
- cellular calcium ion homeostasis
- bone development
- positive regulation of calcium ion import
- endothelial cell morphogenesis
- ossification
- cellular response to glucocorticoid stimulus
- cellular response to cAMP
- chondrocyte proliferation
- negative regulation of calcium ion transport
- cellular response to hypoxia
- negative regulation of endothelial cell migration
- regulation of anion transport
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- hormone activity