Itgb6

Predicted to enable integrin binding activity and molecular function activator activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; integrin-mediated signaling pathway; and transforming growth factor beta production. Predicted to act upstream of or within several processes, including Langerhans cell differentiation; enamel mineralization; and lung development. Predicted to be located in external side of plasma membrane. Predicted to be part of integrin alphav-beta6 complex. Predicted to be active in cell surface and focal adhesion. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (integrin subunit beta 6). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itgb6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Itgb6 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Itgb6 gene, providing context for its role in the cell.